Caryophyllene

Caryophyllene is a spicy, peppery terpene found abundantly in cannabis and black pepper. It is one of the only terpenes that directly interacts with the body's endocannabinoid system by selectively binding to CB2 receptors, exerting analgesic and anti-anxiety properties.

Studies show caryophyllene acts as a natural anti-inflammatory and antioxidant and may help treat depression and addiction according to animal studies. Its pleasant peppery scent also makes caryophyllene commercially useful as a food additive and fragrances. Many common cannabis strains contain significant levels of this multi-purpose terpene.

Future research should further explore the promising therapeutic potential of caryophyllene and its synergy with other cannabis components. Given its compatibility with mammalian CB2 receptors, caryophyllene stands out as a prime candidate to help explain the entourage effect's medical influence.