Phenolic compounds like flavonoids and lignanamides refer to the many antioxidants and biologically active chemicals produced by cannabis plants. Though not essential for basic plant growth, phenolic compounds significantly influence cannabis’ therapeutic effects, color and flavor. For example, a class of antioxidants called cannflavins essentially unique to cannabis demonstrate potent anti-inflammatory properties. Meanwhile, prenylated lignanamides exhibit strong antibacterial effects. Ongoing research seeks to fully characterize the roles of various phenolic compounds in cannabis and maximize extraction methods to harness their health benefits. While complete benefits require more human research, reports clearly show compounds like flavonoids provide antioxidation. Analyzing the phenolic content alongside cannabinoid mapping creates a blueprint of a strain’s therapeutic potential.